A 62-Year-Old Woman Who Discovered a Lump in Her Breast

A 62-year-old woman who discovered a lump in her breast visits the doctor. A hard, immovable, irregularly shaped lump is discovered during a physical examination. A spiculated, calcified lesion that was not visible on earlier investigations is revealed by mammography. The diagnosis of infiltrating ductal carcinoma is made by tissue biopsy. Various degrees of aberrant differentiation and maturation are often linked to malignant tumors, such as infiltrating ductal carcinoma. Which of the following findings is most characteristic of an anaplastic tumor?

A) Brain tumor cells forming giant cells
B) Bronchial epithelial cells producing keratin pearls
C) Colonic tumor cells creating glands
D) Hepatic tumor cells synthesizing bile
E) Skin tumor cells producing keratin pearls