A 45-year-old woman arrives at the office complaining of persistent back pain after two weeks. Over the past few months, she has also experienced severe exhaustion, anorexia, and unintended weight loss. Although the patient has no prior medical issues, there is a family history of cancer. The T10 vertebral body has a lytic lesion, according to imaging studies. The biopsy sample's analysis reveals a cell lineage with abnormally high propensity for replication. An activating mutation is caused by a single nucleotide alteration, according to genetic studies. Which of the following genes is most likely involved in this patient's disease?

Question

Quizplus · Accepted Answer

Eductional Objective: Neoplastic cell development abnormalities can result from proto-oncogene or anti-oncogene mutations (tumor suppressors). Proto-oncogenes promote cell division, and their overexpression or amplification (for example, activating mutation) results in accelerated cellular division and the development of cancer. The proto-oncogene KRAS is frequently turned on in tumor cells, which enhances the cellular responsiveness to mitogenic stimuli.
Anti-oncogenes, on the other hand, are tumor suppressors because they stop cellular growth. Their deactivation (such as a loss-of-function mutation) aids in the growth of tumors. Anti-oncogenes APC, BRCA1, RB, and TP53 are more likely to be inactivated in cancerous cells

A 45-Year-Old Woman Arrives at the Office Complaining of Persistent