A 21-year-old woman is admitted to the hospital for elective subtotal colectomy with ileo-rectal anastomosis due to abnormal colonoscopic findings. Because of a family history of colon cancer, she had a screening colonoscopy. Her maternal grandfather died of metastatic colon cancer, and her mother was recently diagnosed with the disease as well. The patient has no other medical issues, is not on any medications, and does not use tobacco, alcohol, or illegal drugs. There are no operative complications. Numerous lesions are present throughout the resected colon, some of which are depicted in the histopathology exhibit below. 11ec160b 39f4 363d 9249 9b203da374d9 MD0001 00 Genetic testing is most likely to reveal a germline mutation resulting in which of the following effects?

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Eductional Objective: Familial adenomatous polyposis is an autosomal-dominant hereditary disorder that causes numerous colonic polyps and a nearly 100% risk of colorectal cancer. It is caused by a germline mutation in the tumor suppressor gene adenomatous polyposis coli.

A 21-Year-Old Woman Is Admitted to the Hospital for Elective