A 26-year-old male with myalgia, nasal congestion, and a cough shows up at the clinic. It is 38.3 C outside (100.9 F). On examination, hyperemia is seen in the nose and throat. Nasopharyngeal secretions tested quickly for influenza antigen are positive. Viral proteins are broken down and bound to major histocompatibility complex class I molecules within the infected cells of the patient's respiratory tract. These molecules are subsequently produced on the cell surface for presentation to cytotoxic CD8+ lymphocytes. Which of the following enzymes is most essential to initiating this process?

Question

Quizplus · Accepted Answer

Eductional Objective: The ubiquitin proteasome pathway's destruction of intracellular viral proteins is a crucial step in the activation of the cellular immune response to a virus. Ubiquitin ligases, which identify particular protein substrates and add a ubiquitin tag, start this route. The major histocompatibility complex class I proteins are associated with the target proteins, which are then broken down by a proteasome into peptide fragments, and displayed on the cell surface for cytotoxic CD8+ lymphocyte monitoring.

A 26-Year-Old Male with Myalgia, Nasal Congestion, and a Cough