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A 12-Month-Old Girl Is Brought to the Physician by His

Question 402

Multiple Choice

A 12-month-old girl is brought to the physician by his parents for a well-child check. Her mother is concerned because she is unable to sit and has not learned how to crawl. She attained neck control at 4 months and could roll from front to back at 5 months of age. She does not engage in play, reach for toys, or maintain eye contact. She babbles and does not mimic sounds. She does not follow simple instructions. Her vital signs are within normal limits. She is at the 25th percentile for length and 10th percentile for weight. Neurological examination shows increased muscle tone in all extremities. The ankle clonus and extensor plantar responses are present bilaterally. Which of the following is the most likely cause of this patient's condition?


A) Brachial plexus injury
B) Diffuse cerebral atrophy
C) Holoprosencephaly
D) Mesial temporal sclerosis
E) Periventricular focal necrosis

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