A 7-year-old girl is brought to the physician for a well-child examination. She is at 95th percentile for height and 70th percentile for weight. Examination shows elevated breast buds that extend beyond the areola. Coarse pubic and axillary hair is present. The external genitalia appear normal. An x-ray of the left wrist shows a bone age of 10 years. Serum luteinizing hormone levels do not increase following GnRH agonist stimulation. Which of the following is most likely secreted by this patient's tumor?

Question

Quizplus · Accepted Answer

Eductional Objective: Granulosa cell tumors are sex-cord stromal tumors of the ovary that secrete estrogen and can cause endometrial hyperplasia.  Call-Exner bodies (cells arranged in a microfollicular or rosette pattern) are seen on microscopy.  On gross pathology, the tumor appears yellow due to the lipid content in theca cells.

A 7-Year-Old Girl Is Brought to the Physician for a Well-Child