A 42-year-old lady visits her doctor for an usual check-up. She does not have any current problems and no major medical history. During a medical examination, the doctor notices lesions on her eyelids, which are depicted below. His father died of a heart attack at the age of 40. Assuming this patient's disease had a genetic basis, poor receptor expression in which of the following organs is most likely responsible for his condition?

Question

A 42-year-old lady visits her doctor for an usual check-up. She does not have any current problems and no major medical history. During a medical examination, the doctor notices lesions on her eyelids, which are depicted below.  His father died of a heart attack at the age of 40.  Assuming this patient's disease had a genetic basis, poor receptor expression in which of the following organs is most likely responsible for his condition?

Quizplus · Accepted Answer

Eductional Objective: One of the most frequent autosomal dominant illnesses, familial hypercholesterolemia, is caused by heterozygous or homozygous LDL receptor gene mutations, which result in hepatocyte under-expression of functioning LDL receptors. This syndrome can result in accelerated atherosclerosis and the beginning of coronary artery disease at a young age.

A 42-Year-Old Lady Visits Her Doctor for an Usual Check-Up