A 26-year-old woman arrives at the clinic with a skin issue. The patient has had dry, flaky skin since infancy, but it has recently deteriorated. Symptoms usually worsen in the winter and ease when the temperature warms up in the spring. The patient comes from an asthmatic background, and both parents have persistently dry skin. As seen in the exhibit, examination reveals widespread scaling of the skin, particularly on the extremities. Which of the following is the most likely cause of this patient's condition?

Question

A 26-year-old woman arrives at the clinic with a skin issue. The patient has had dry, flaky skin since infancy, but it has recently deteriorated. Symptoms usually worsen in the winter and ease when the temperature warms up in the spring. The patient comes from an asthmatic background, and both parents have persistently dry skin. As seen in the exhibit, examination reveals widespread scaling of the skin, particularly on the extremities.   Which of the following is the most likely cause of this patient's condition?

Quizplus · Accepted Answer

Eductional Objective: Filaggrin gene mutations induce keratinocyte desquamation defects, resulting in ichthyosis vulgaris. It is distinguished by dry, scaly skin; symptoms are widespread but usually severe on the trunk and extensor surfaces of the extremities.

A 26-Year-Old Woman Arrives at the Clinic with a Skin