A 45-year-old woman comes to the office to discuss low bone density. The patient was diagnosed with a prolactinoma 4 years ago after she lost her menstrual period for 6 months, but she refused medical or surgical treatments Family history is unremarkable. Laboratory studies show an increased serum prolactin level, a normal TSH level, and an undetectable B-hCG concentration. A DEXA scan shows an osteopenia of her bone. The underlying mechanism for this patient's osteopenia is most likely to cause which of the following additional manifestations?

Question

A 45-year-old woman comes to the office to discuss low bone density.  The patient was diagnosed with a prolactinoma 4 years ago after she lost her menstrual period for 6 months, but she refused medical or surgical treatments  Family history is unremarkable.  Laboratory studies show an increased serum prolactin level, a normal TSH level, and an undetectable B-hCG concentration.  A DEXA scan shows an osteopenia of her bone. The underlying mechanism for this patient's osteopenia is most likely to cause which of the following additional manifestations?

Quizplus · Accepted Answer

Eductional Objective: In patients with prolactinoma, high levels of circulating prolactin suppress GnRH secretion from the hypothalamus, leading to reduced secretion of LH and subsequent hypogonadism, anovulation, and amenorrhea.  The resulting estrogen deficiency can cause osteoporosis with an increased risk for fragility fractures, and lead to vaginal dryness and atrophy.

A 45-Year-Old Woman Comes to the Office to Discuss Low