A 43-year-old woman agrees to participate in a clinical trial for a medication for type 2 diabetes mellitus. She was diagnosed with diabetes mellitus 5 years ago, and despite taking the maximum tolerated dose of metformin, her blood sugar has recently been uncontrolled. The subject's medical history is otherwise unremarkable, and she is not taking any medications that would preclude her from participating in the trial. According to preliminary laboratory findings, fasting glucose is 155 mg/dL and hemoglobin A1c is 8.2 percent. Other screening tests are normal, and a urine pregnancy test is negative. The research drug stimulates the nuclear receptor and transcription factor peroxisome proliferator-activated receptor gamma. Activation of this receptor would most likely result in which of the following metabolic changes?

Question

Quizplus · Accepted Answer

Eductional Objective: Thiazolidinediones (TZDs) reduce blood glucose levels by reducing insulin resistance. TZDs activate the nuclear receptor peroxisome proliferator-activated receptor gamma, which changes the transcription of genes involved in glucose and lipid metabolism.

A 43-Year-Old Woman Agrees to Participate in a Clinical Trial