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A 60-Year-Old Woman Comes to the Physician Because of a 7-Month

Question 253

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A 60-year-old woman comes to the physician because of a 7-month history of left knee pain and stiffness. The patient has attempted treatment with acetaminophen, but that has not provided adequate relief. Examination of the left knee shows tenderness to palpation along the joint line; there is crepitus with full flexion and extension. An x-ray of the knee shows osteophytes with joint-space narrowing. Arthrocentesis of the knee joint yields clear fluid with a leukocyte count of 120/mm3. Treatment with celecoxib therapy is planned. The presence of which of the following conditions in this patient's medical history would make this medication the preferred treatment?


A) Hyperlipidemia
B) Hypertension
C) Peptic ulcer disease
D) Renal impairment
E) Stable angina

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