A 67-year-old woman comes to the physician for a routine health maintenance examination. She has a history of hypertension and has smoked a pack of cigarettes daily for 30 years. BMI is 20.1 kg/m². Physical examination is unremarkable.. A screening DEXA scan shows a low bone density at the femur. The patient is prescribed risedronate. Repeat bone densitometry 2 years later reveals no further loss of bone mineral density. Which of the following mechanisms most likely explains the drug's effect on bone mineral density?

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Eductional Objective: Bisphosphonates primarily slow down the degradation of bone substance by interfering with osteoclast function, which bind to hydroxyapatite binding sites on the surface of bone tissue then uptake by osteoclasts during phases of bone resorption which interference with osteoclast function and promotion of osteoclast apoptosis and leads to reduce bone resorption

A 67-Year-Old Woman Comes to the Physician for a Routine