A 16-year-old girl is brought to the physician by her father because of a dry cough, and intermittent wheezing during the past 3 months. Since birth, she has had four upper respiratory tract infections that resolved without treatment and one episode of acute otitis media treated with antibiotics. She has a history of eczema. She is diagnosed with asthma and she is started on inhaled beta-agonist and inhaled glucocorticoid therapy. On next follow up visit, her father is concerned about glucocorticoid side effects and growth retardation and he asks to stop use it and switch to another medication. She is started on a trial of inhaled cromolyn. Which of the following is the most likely site of action of this new medication?

Question

Quizplus · Accepted Answer

Eductional Objective: Cromolyn and nedocromil are mast cell-stabilizing agents that inhibit mast cell degranulation independent of the triggering stimulus.  They are less effective than inhaled glucocorticoids and are considered second-line treatments for allergic rhinitis and bronchial asthma.

A 16-Year-Old Girl Is Brought to the Physician by Her