A 59-year-old woman comes to the physician because of left leg swelling that started after a long time flight. A duplex ultrasound of the left leg shows a noncompressible popliteal vein. A drug is prescribed that prolongs activated partial thromboplastin time and prothrombin time in a dose-dependent manner but has no effect on thrombin time. Which of the following agents was this patient most likely administered?

Question

A 59-year-old woman comes to the physician because of left leg swelling that started after a long time flight. A duplex ultrasound of the left leg shows a noncompressible popliteal vein. A drug is prescribed that prolongs activated partial thromboplastin time and prothrombin time in a dose-dependent manner but has no effect on thrombin time.  Which of the following agents was this patient most likely administered?

Quizplus · Accepted Answer

Eductional Objective: Direct factor Xa inhibitors (eg, apixaban, rivaroxaban) increase the prothrombin and activated partial thromboplastin times but do not affect the thrombin time.  Unfractionated heparin and direct thrombin inhibitors (eg, dabigatran) prolong the thrombin time.

A 59-Year-Old Woman Comes to the Physician Because of Left