A 47-year-old man visits the office for a check-up on his high blood pressure. The medical history of the patient is significant for stable angina pectoris, for which he takes sublingual nitroglycerin as needed. He does not have orthopnea, nocturnal dyspnea, or lower extremity swelling. His blood pressure is 154/107 mm Hg, and his pulse rate is 86 beats per minute. A physical examination reveals no anomalies. The patient is given a low dose of atenolol to begin with. Which of the following cellular changes will most likely occur as a direct effect of this medication?

Question

Quizplus · Accepted Answer

Eductional Objective: There are Beta 1 adrenergic receptors in cardiac tissue and renal juxtaglomerular cells, but none in vascular smooth muscle. Selective blockade of the 1 receptor (for example, with atenolol) reduces cAMP levels in cardiac and renal tissue while having no effect on cAMP levels in vascular smooth muscle.

A 47-Year-Old Man Visits the Office for a Check-Up on His