A 5-year-old girl is brought to the emergency department because of a severe nosebleed 3 days after her grandmother found her next to an empty bottle that contained warfarin. The girl's pulse is 134/min, and blood pressure is 87/44 mm Hg. Physical examination shows brisk, bilateral epistaxis that persists despite compression and nasal packing. Laboratory studies show normocytic anemia and increased prothrombin and partial thromboplastin times. Which of the following is the most appropriate therapy to immediately reverse her current condition?

Question

Quizplus · Accepted Answer

Eductional Objective: Fresh frozen plasma (FFP) contains all functional clotting factors and should be given immediately in cases of severe bleeding caused by warfarin, a vitamin K antagonist that leads to depletion of factors II, VII, IX, and X. Vitamin K should also be given, although it does not have a therapeutic effect until several hours after administration. FFP should also be given in cases of brodifacoum poisoning, a long-acting warfarin derivative that is commonly used in rodent poisons.

A 5-Year-Old Girl Is Brought to the Emergency Department Because