Fifty obese adults without diabetes mellitus are enrolled in a 10-week weight loss program. The program includes a low-calorie diet and moderate-intensity exercise for at least 150 minutes per week. The study subjects who are adherent to the regimen lose an average of 7 kg (15.5 lb) at the end of 10 weeks. Venous blood samples to study biochemical changes induced by weight loss are taken at the start of the trial and at the 10-week follow-up visit. Which of the following hormonal changes are likely to occur during the course of the study?

Question

Fifty obese adults without diabetes mellitus are enrolled in a 10-week weight loss program.  The program includes a low-calorie diet and moderate-intensity exercise for at least 150 minutes per week.  The study subjects who are adherent to the regimen lose an average of 7 kg (15.5 lb) at the end of 10 weeks.  Venous blood samples to study biochemical changes induced by weight loss are taken at the start of the trial and at the 10-week follow-up visit.  Which of the following hormonal changes are likely to occur during the course of the study?

Quizplus · Accepted Answer

Eductional Objective: Ghrelin increases hunger and encourages weight gain. In the CNS, leptin and insulin reduce hunger. Caloric restriction raises ghrelin levels while lowering leptin and insulin levels, which increases hunger and might make it challenging to sustain weight reduction.

Fifty Obese Adults Without Diabetes Mellitus Are Enrolled in a 10-Week