A 30-year-old woman comes to the office because of increase urination. She has also dry mouth and excessive thirst despite drinking several gallons of water daily. She has no significant medical conditions and takes no medications. Her blood glucose level is 80 mg/dL. A standard water deprivation test is performed. The results of urine osmolality during 4 hours of dehydration are presented in the table below. The patient's plasma osmolality after 3 hours of water deprivation was found to be 298 mOsm/L, and vasopressin was then administered subcutaneously. Which of the following is the most likely diagnosis in this patient?

Question

Quizplus · Accepted Answer

Eductional Objective: In diabetes insipidus, patient has I): polyuria, polydipsia, dehydration, hypernatremia, and decreased urine osmolality (< 300 mOsmol/kg). If a desmopressin is administered after water deprivation test, then it leads to increase urine osmolality in central DI but not in nephrogenic DI.

A 30-Year-Old Woman Comes to the Office Because of Increase