Which One of the Following Is NOT True About Targeted

Which one of the following is NOT true about targeted gene delivery?

A) Coating of DNA complexes with folate-based chemical conjugates helps specific targeting of cells expressing folate receptors.
B) pH sensitive complexes are acid-sensitive complex that disassembles and release DNA at certain pH values of the environment.
C) Cancer specific gene delivery is achievable upon coating DNA complexes with antibodies recognizing cancer specific antigens.
D) Targeted gene transcription is the use of synthetic promoters helping in preferential accumulation of DNA complexes in cells where these promoters are active.
E) Colon cancers can be transcriptionally targeted by using promoters activated by β-catenin pathway.