An 8 year old Caucasian male presents to your office with complaints of bilateral upper arm pain x 1 month. The pain denies any recent trauma to the area. He states that the achy, localized pain is a 6/10 and is worse in the mornings. His mother has tried Ibuprofen to alleviate some symptoms but the pain often returns. There is no FHx of bone cancers. No signs of child neglect or abuse. Upon examination there is point tenderness along each humerus but no swelling or ecchymosis. The patient has full ROM and 4/5 strength bilaterally in his upper extremities. X-ray reveals opacity and multiple hairline fractures in the humerus. The patient is referred to a rheumatologist. If this patient is found to have a mutation in the LRP5 gene, what region of the humerus would you expect the hairline fractures to be located?
A) Epiphysis
B) Epiphyseal Plate
C) Metaphysis
D) Diaphysis
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