A 58-year-old white male is concerned about his recent 20-pound weight loss and recurrent fevers at night. On exam, he has splenomegaly. His CBC shows a WBC count of 95,000 with 20% blasts. Upon chromosomal analysis, it was determined that the there is a translocation of chromosomes 9 and 22. He was diagnosed with chronic myelogenous leukemia. What gene is associated with this disease?

Question

Quizplus · Accepted Answer

The patient described has chronic myelogenous leukemia and the gene associated with this disease is bcr/abl. Answer A is incorrect, BRCA2 is linked to breast cancer, ovarian cancer, prostate cancer, pancreatic cancer, and melanoma. Answer C is incorrect, BRCA1 is linked to breast cancer, ovarian cancer, prostate cancer, pancreatic cancer, and colon cancer. Answer D is incorrect because p53 is a tumor suppressor gene related to Li-Fraumeni syndrome. Answer B is correct.

A 58-Year-Old White Male Is Concerned About His Recent 20-Pound