Most vaginal, vulvar, and anal malignancies (90-95%) are squamous cell carcinomas that arise from the stratified epithelium that covers these anatomic sites.

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Squamous cell carcinomas are the most common type of cancer in these areas because they originate from the stratified squamous epithelium, which is the predominant tissue type in the vagina, vulva, and anus.

Most Vaginal, Vulvar, and Anal Malignancies (90-95%) Are Squamous Cell