You perform a series of voltage-clamp experiments with 2 mM extracellular calcium, 0.2 mM extracellular calcium and 0 mM extracellular calcium. You notice that the potassium current increases with each step. What is the origin of this increase?

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Quizplus · Accepted Answer

The increase in potassium current with each step of reducing extracellular calcium concentration is due to the activation of calcium-activated potassium channels. These channels open in response to intracellular calcium levels, and their activation leads to an increase in potassium current, which can be observed in the experiments described.

You Perform a Series of Voltage-Clamp Experiments with 2 MM