Which of the following accounts for allelic exclusion in rearrangement within the IgH locus?
A) Rearrangement only occurs on one homolog at a time, and once one homolog has successfully rearranged, the other is methylated to produce heterochromatin.
B) Rearrangement is regulated by VpreB and ? 5, which are themselves only expressed at specific times during IgH rearrangement
C) Both homologs rearrange simultaneously, undergoing multiple V-J rearrangements until a productive one occurs.
D) All of the answers promote allelic exclusion in IgH.
E) None of the answers are correct; allelic exclusion does not occur in IgH.
Correct Answer:
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