Why Are the Mycobacterial Infections Difficult to Treat with Antibiotics

Why are the Mycobacterial infections difficult to treat with antibiotics? (Select all that apply)

A) The waxy cell wall created by the inclusion of mycolic acids is difficult for most antibacterial agent to permeate.
B) Members of this genus grow very slowly requiring long-term therapy that leads to potential antimicrobial agent toxicity.
C) Because appropriate antibiotics have to be taken for long periods of time patients are less likely to keep taking them.
D) The outer membrane has small porins that restrict the diffusion of antibacterial agents into the cell.