Antimetabolites such as methotrexate attack the cells at the S phase of the cell cycle because they interfere with purine and pyrimidine biosynthesis.

Question

Quizplus · Accepted Answer

Antimetabolites such as methotrexate indeed attack cells at the S-phase of the cell cycle. This is because S-phase is the part of the cell cycle where DNA replication occurs, and the cells need purine and pyrimidine nucleotides to synthesize DNA. Antimetabolites interfere with nucleotide biosynthesis, which stops DNA replication and halts cell division. Therefore, both parts of the statement are true.

Antimetabolites Such as Methotrexate Attack the Cells at the S