Which of the Following Statements Correctly Describe the Behaviour of Metals

Which of the following statements correctly describe the behaviour of metals as components of metalloenzymes? Please select all that apply.

A) The metal ions in a metalloenzyme may be coordinated to a variable number of atoms during the course of a reaction
B) Metal ions in a metalloenzyme do not participate chemically in the reaction being catalyzed by the enzyme
C) Metals are often located in the active site of metalloenzymes
D) Metals in metalloenzymes may not obey the octet rule