Using parabiotic mice to investigate genetic influences on obesity,it was found that:
A)If db/db mice were paired with normal mice,the normal mice starved.
B)If db/db mice were paired with ob/ob mice,the ob/ob mice starved.
C)Paired ob/ob mice with normal mice slowed the weight gain of ob/ob mice.
D)All of the above are true.

Question

Quizplus · Accepted Answer

All of the statements are true. Parabiotic pairing, where two mice share a circulatory system, has been used to study the genetic influences on obesity. In these experiments, db/db mice, which overeat due to a lack of leptin receptors, cause normal mice to starve because the db/db mice consume most of the shared nutrients. When db/db mice are paired with ob/ob mice, which are obese due to a lack of leptin, the ob/ob mice starve for similar reasons. Pairing ob/ob mice with normal mice slows the weight gain of ob/ob mice because the normal mouse produces leptin, which is shared through the circulatory connection, partially correcting the ob/ob mouse's deficiency.

Using Parabiotic Mice to Investigate Genetic Influences on Obesity,it Was