Which one of the following molecules does NOT play an important role in the class II MHC pathway of antigen presentation?
A)β₂-Microglobulin
B)Cathepsin
C)Invariant chain
D)HLA-DM
E)Calnexin

Question

Quizplus · Accepted Answer

β₂-Microglobulin is one of the polypeptide chains of a class I MHC molecule and is required for assembly of the peptide-class I MHC complex. All the other molecules listed are involved in the class II MHC of antigen presentation. Cathepsins are acid proteases that degrade proteins in acidic vesicles in the class II MHC pathway. The invariant chain directs appropriate sorting of new class II MHC molecules from the Golgi to endosomes, and it protects the class II MHC peptide binding groove from occupancy by peptides until the class II MHC molecules are delivered to the endosome. Calnexin is an endoplasmic reticulum chaperone involved in the assembly of both class I and class II molecules.

Which One of the Following Molecules Does NOT Play an Important