The induction phase of a cell-mediated immune response includes which of the following events?
A)CD4⁺ T cell secretion of interferon-ƴ leading to macrophage activation
B)CD8⁺ T cell lysis of a virally infected cell
C)Clonal expansion of CD8⁺ T cells within a lymph node
D)Migration of CD4⁺ effector T cells from blood vessels into a tissue site of infection
E)Migration of a naive CD4⁺ T cell from the thymic medulla into the circulation

Question

Quizplus · Accepted Answer

The induction phase of cell-mediated immune responses occurs in lymphoid tissues and includes antigen presentation to naive T cells, leading to clonal expansion and differentiation of those T cells into effector cells. Migration into infection sites and interferon-ƴ secretion by CD4⁺ helper T cells, as well as target cell killing by CD8⁺CTL, are part of the effector phases of cell-mediated immune responses. Naive T cell migration out of the thymus is the last step in T cell maturation and occurs regardless of the presence of antigen.

The Induction Phase of a Cell-Mediated Immune Response Includes Which