A scientist notices that cells being grown in culture have ceased to divide. Further investigation demonstrates the cells have abnormally segregated chromosomes. Which checkpoint are these cells likely arrested at?
A) Spindle assembly checkpoint
B) DNA damage checkpoint
C) START
D) Restriction checkpoint

Question

Quizplus · Accepted Answer

The spindle assembly checkpoint ensures that all chromosomes are attached to the spindle fibers before the cell progresses to metaphase. If the chromosomes are not properly aligned, the checkpoint will arrest the cell cycle at this point. Abnormal chromosome segregation indicates that there is likely an issue with spindle assembly, making the spindle assembly checkpoint the likely checkpoint at which the cells are arrested.

A Scientist Notices That Cells Being Grown in Culture Have