A major difference between eukaryotic and prokaryotic RNA polymerases is that eukaryotic polymerases
A) use a set of transcription factors to bind to and initiate transcription.
B) use sigma ($\sigma$) factors to initiate transcription.
C) start from promoters.
D) start from origins of replication.

Question

Quizplus · Accepted Answer

Eukaryotic RNA polymerases require a set of transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and TFIIH) to bind to specific DNA sequences called promoters and initiate transcription. Prokaryotic RNA polymerases do not require transcription factors but instead use sigma factors to bind to specific DNA sequences and initiate transcription.

A Major Difference Between Eukaryotic and Prokaryotic RNA Polymerases Is σ\sigmaσ

A Major Difference Between Eukaryotic and Prokaryotic RNA Polymerases Is $\sigma$