If only the postsynaptic or only the presynaptic neurons fire, then LTP is not observed. This neural phenomenon accords with:

Question

Quizplus · Accepted Answer

The Rescorla-Wagner model explains that for learning to occur, there must be a surprise or an unpredicted event. In the context of Long-Term Potentiation (LTP), both pre- and postsynaptic neurons need to be active for LTP to occur, aligning with the model's prediction that both a conditioned stimulus (presynaptic activity) and an unconditioned stimulus (postsynaptic activity) need to coincide for learning (LTP) to happen.

If Only the Postsynaptic or Only the Presynaptic Neurons Fire