Some diuretics are aldosterone receptor antagonists, such as spironolactone and eplerenone. Aldosterone increases

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Aldosterone increases the activity of an apical Na+ channel, which leads to increased reabsorption of Na+ in the kidneys, and ultimately increased water retention. Aldosterone receptor antagonists, such as spironolactone and eplerenone, block the effects of aldosterone and promote diuresis.

Some Diuretics Are Aldosterone Receptor Antagonists, Such as Spironolactone and Eplerenone