Animal studies on the acute and chronic effects of antidepressants on serotonin have shown that
A) the autoreceptors are activated acutely, causing a decrease in synthesis and release of 5-HT.
B) the reuptake transporters remain open for the duration of the drug's action.
C) tolerance to the drug occurs at the autoreceptors sporadically, resulting in reduced 5-HT release.
D) serotonin occupancy of serotonin autoreceptors activates cell firing following chronic antidepressant treatment.
Correct Answer:
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