The sickle-cell gene is found in high frequency in certain African countries mainly along the equator because:

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The sickle-cell gene is found in high frequency in certain African countries mainly along the equator because it confers some natural selection advantage. People with sickle-cell heterozygous state are more resistant to malaria, which is endemic in these regions, and this gives a selective advantage to carrying the gene.

The Sickle-Cell Gene Is Found in High Frequency in Certain