Recreational drugs, such as PCP and ketamine, lead to schizophrenia-like symptoms by ________.

Question

Quizplus · Accepted Answer

Recreational drugs like PCP and ketamine lead to schizophrenia-like symptoms primarily by impairing the functioning of glutamate and one of its receptors, NMDA (N-methyl-D-aspartate). These substances are known to be NMDA receptor antagonists, which block the action of glutamate, a neurotransmitter crucial for learning and memory. This disruption in glutamate signaling is thought to contribute to the manifestation of symptoms similar to those observed in schizophrenia.

Recreational Drugs, Such as PCP and Ketamine, Lead to Schizophrenia-Like