Caffeine's metabolic half-life ranges between 6 and 12 hours. Caffeine clears the body in about 2 hours before it's blood caffeine concentration decreases by one-half. As a frame of reference, it requires about 10 hours for clearance of other stimulants like methamphetamine.

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Quizplus · Accepted Answer

Caffeine's metabolic half-life indeed ranges between 3 to 5 hours for most people, meaning it takes this amount of time for the blood caffeine concentration to decrease by one-half, not 2 hours as stated. The clearance time can vary based on individual factors such as age, liver function, and other medications.

Caffeine's Metabolic Half-Life Ranges Between 6 and 12 Hours