Which of the following situations is most likely to result in an increased binding affinity of hemoglobin for oxygen?

Question

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As each binding site on a hemoglobin molecule is occupied, the affinity of the remaining sites for oxygen binding is increased. Increased affinity is associated with alkalosis, not acidosis, and fever causes reduced affinity. Exercise increases the unloading of oxygen, a situation characterized by low affinity.

Which of the Following Situations Is Most Likely to Result