Patients with "Hispanic thalassemia" have a deletion of the ________ of the beta-globin gene cluster that results in silencing of the genes.

Question

Quizplus · Accepted Answer

The locus control region (LCR) is crucial for the regulation of the beta-globin gene cluster. Its deletion in "Hispanic thalassemia" leads to the silencing of the genes, as the LCR is responsible for the high-level expression of these genes in erythroid cells.

Patients with "Hispanic Thalassemia" Have a Deletion of the ________