As the Concentration of Macromolecules Such as Lipids and Proteins

As the concentration of macromolecules such as lipids and proteins increases:

A) methods that measure ions in plasma water will show an increase in the concentration/activity measured, although the physiological activity is normal.
B) methods that measure ions in plasma water will show a decrease in the concentration/activity measured, although the physiological activity is normal.
C) methods that measure ions in total plasma volume will show an increase in the concentration/activity measured, although the physiological activity is normal.
D) methods that measure ions in total plasma volume will show a decrease in the concentration/activity measured, although the physiological activity is normal.