The following data provide laboratory evidence of which lipoprotein abnormality?
Total cholesterol - decreased, triglycerides - decreased
Apoprotein B - decreased
Vitamin E - decreased
Red blood cell morphology - acanthocytosis

Question

Quizplus · Accepted Answer

Patients with abetalipoproteinemia have undetectable plasma concentrations of LDL cholesterol and apoB.The plasma cholesterol concentration does not exceed 80mg/dL and is likely to be no higher than 30mg/dL.This is accompanied by concentrations of triglycerides lower than those seen in any other disease-usually < 20mg/dL.After a fat load, chylomicrons do not appear in plasma.Patients with abetalipoproteinemia suffer from fat malabsorption (steatorrhea) and low vitamin E concentrations.Vitamin E is essential for neurological function and is transported in plasma in association with the apoB-containing lipoproteins.Acanthocytosis is found in abetalipoproteinemia, with acanthocytes comprising 50% to 100% of circulating erythrocytes.The acanthocytosis found in ABL could be a result of either vitamin E deficiency or an altered membrane lipid composition.

The Following Data Provide Laboratory Evidence of Which Lipoprotein Abnormality