Diagnosis of Multiple Myeloma Is Made by Which of the Following

Diagnosis of multiple myeloma is made by which of the following criteria?
1) a monoclonal M protein in the plasma or urine
2) infiltration of plasma cells in the bone marrow
3) lytic lesions on radiographs of the skeleton
4) hypocalcemia

A) 1, 2, 3
B) 1, 2, 4
C) 1, 3, 4
D) 2, 3, 4