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A 38-Year-Old Man Is Admitted to the Hospital for Laboratory

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A 38-year-old man is admitted to the hospital for laboratory tests. When seen by his physician, he complains of increasing tiredness and muscular weakness over the previous year. He has experienced five attacks of nausea and vomiting, and diarrhea during this period. His reason for visiting his physician is that his friends have noticed that his skin is becoming darker. After a complete physical examination, a diagnosis of Addison's disease is made, and it is confirmed by laboratory tests. What is the cause of Addison's disease? The secretions of which hormones are defective in this disease? What is responsible for the weakness and increased pigmentation of the skin in this condition?

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Addison's disease occurs as a result of ...

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