What microbe has both a live-attenuated vaccine and an inactivated vaccine currently in routine use? The inactivated one is used for anyone under 2 years or over 60, or for anyone who is immunocompromised in any way.

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Quizplus · Accepted Answer

Besides the clues of both alive and killed vaccines in routine use, the question noted the vaccine was given across the spectrum of ages. Of the vaccines listed, only pneumococcal, DTP, and influenza fit that criterion. Two influenza vaccines are in current use. The live (attenuated) one is given intranasally and the killed (inactivated) one is injected. Streptococcus pneumoniae does have two vaccines, but neither is live attenuated; the pediatric pneumococcal vaccine is 13 (used to be 7)-capsular polysaccharides chemically complexed to protein. The 23-valent polysaccharide pneumococcal vaccine is used for anyone 65 years and older. Choice C is poliovirus; in the United States, the attenuated strains were previously routinely used to vaccinate (Sabin vaccine given orally), but the incidence of vaccine-associated polio became too high. The United States then switched to an injectable, inactivated tetravalent polio vaccine. Hepatitis B vaccine is a recombinant, single component vaccine with only the HBsAg present.

What Microbe Has Both a Live-Attenuated Vaccine and an Inactivated