When fatty acids with odd numbers of carbon atoms are oxidized in the b-oxidation pathway the final product is 1 mole of acetyl-CoA and 1 mole of the 3-carbon molecule, propionyl-CoA. In order to use the propionyl carbons, the molecule is carboxylated and converted ultimately to succinyl-CoA and fed into the TCA cycle. Which of the following represents the vitamin cofactor required in one of the steps of this conversion?

Question

Quizplus · Accepted Answer

Cobalamin (B12) is required for the conversion of methylmalonyl-CoA to succinyl-CoA in the metabolism of propionyl-CoA.

When Fatty Acids with Odd Numbers of Carbon Atoms Are