A 13-Year-Old Girl Presents with Extensive Eruptive Xanthomas and Hepatosplenomegaly

A 13-year-old girl presents with extensive eruptive xanthomas and hepatosplenomegaly. She does not have type 1 or type 2 diabetes as an analysis of circulating insulin and glucose levels indicates they are normal. Examination of plasma indicates that it quite milky, indicating a lipemia. Analysis of the lipid content of the plasma shows a massive accumulation of chylomicrons and triglycerides. The teenager is placed on a fat-free diet, which reduces the lipemia and all of the other clinical manifestations. A deficiency in which of the following apolipoproteins would account for the observed symptoms of this particular hyperlipoproteinemia?

A) apoA-I
B) apoA-IV
C) apoB-100
D) apoC-II
E) apoE