Creatine phosphate is a critically important molecule for the storage of readily available energy in skeletal muscle. The synthesis of creatine phosphate requires the input of which of the following amino acids?

Question

Quizplus · Accepted Answer

Creatine phosphate synthesis involves the amino acid arginine, which, along with glycine and methionine, is used in the biosynthesis of creatine.  Creatine is synthesized in the liver by methylation of guanidoacetate using SAM as the methyl donor. Guanidoacetate itself is formed in the kidney from the amino acids arginine and glycine. Creatine is used as a storage form of high energy phosphate. The phosphate of ATP is transferred to creatine, generating creatine phosphate, through the action of creatine phosphokinase. The reaction is reversible such that when energy demand is high (eg, during muscle exertion) creatine phosphate donates its phosphate to ADP to yield ATP.

Creatine Phosphate Is a Critically Important Molecule for the Storage