You are carrying out experiments designed to increase energy expenditure as a therapeutic means to treat obesity. You are testing various compounds in experimental animals and find one that appears to satisfy the goals of the experiment in that mice given the compound have a significant increase in thermogenic activity in their adipose tissue. This compound is most likely activating or mimicking the activity of which of the following?

Question

Quizplus · Accepted Answer

UCP1 (Uncoupling Protein 1) is involved in thermogenesis in brown adipose tissue, leading to increased energy expenditure and heat production, which aligns with the observed increase in thermogenic activity in the experiment. Uncoupling protein 1 (UCP1) is a mitochondrial protein of brown adipose tissue (BAT) involved in the process of adaptive thermogenesis. In response to hormonal stimulation of BAT, there is an increase in fatty acid release from triglycerides. The fatty acids enter the mitochondria and activate the mitochondrial uncoupling activity of UCP1. This uncoupling releases the mitochondrial proton gradient as heat

You Are Carrying Out Experiments Designed to Increase Energy Expenditure