Patients with poorly controlled Type 1 diabetes exhibit elevated plasma glucose concentration. The increases result in part because, in the absence of insulin, there is a lack of induction of glucokinase in which of the following organs?

Question

Quizplus · Accepted Answer

In Type 1 diabetes, the absence of insulin leads to a lack of induction of glucokinase in the liver, which is crucial for glucose metabolism and regulation. Insulin action involves the regulation of the activities of numerous enzymes as well as the expression of the genes encoding many of the same enzymes. One of the hepatic genes regulated by insulin is glucokinase. Reduced expression of glucokinase lowers the ability of the liver to phosphorylate and utilize glucose, thus contributing to the hyperglycemia in the absence of proper insulin administration in Type 1 diabetics.

Patients with Poorly Controlled Type 1 Diabetes Exhibit Elevated Plasma